Thermo Fisher Scientific DTL Polyclonal Antibody
Human DTL 단백질에 특이적인 Rabbit Polyclonal Antibody로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품이며, PBS와 글리세롤 버퍼에 보관. 세포 주기 조절 및 DNA 손상 반응 연구용으로 적합.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human DTL. Recombinant protein control fragment (Product #RP-105875). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856446 |
Product Specific Information
Immunogen sequence:
RVKRRLDSSC LESVKQKCVK SCNCVTELDG QVENLHLDLC CLAGNQEDLS KDSLGPTKSS KIEGAGTSIS EPPSPISPYA SESCGTLPLP LRPCGEGSE
Target Information
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response, and translesion DNA synthesis.
The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1).
CDT1 degradation in response to DNA damage ensures proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential for replication licensing control.
Most substrates interact with PCNA via their PIP-box, and those containing the K+4 motif recruit the DCX(DTL) complex, leading to their degradation.
In undamaged proliferating cells, the DCX(DTL) complex promotes Lys-164 monoubiquitination of PCNA, being involved in PCNA-dependent translesion DNA synthesis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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