Thermo Fisher Scientific GNA11 Polyclonal Antibody
Human GNA11 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되어 높은 특이도와 재현성을 제공. 연구용으로 G단백질 신호전달 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GNAQ. Recombinant protein control fragment (Product # RP-104441) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642081 |
Product Specific Information
- Immunogen sequence: SDNENRMEES KALFRTIITY PWFQNS
- Antigen sequence identity: Mouse – 100%, Rat – 100%
Target Information
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β, and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines, and sensory stimuli. Over 20 known Gα subunits have been classified into four families — Gα(s), Gα(i/o), Gα(q), and Gα(12) — based on structural and functional similarities. Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, as substitution with phenylalanine alters receptor interaction and abolishes ligand-induced IP3 formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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