Thermo Fisher Scientific SERCA2 ATPase Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
TVEEVLGHFG VNESTGLSLE QVKKLKERWG SNELPA

Target Information

This gene encodes one of the SERCA Ca(2+)-ATPases, intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. The enzyme catalyzes ATP hydrolysis coupled with calcium translocation from cytosol into the sarcoplasmic reticulum lumen, regulating muscle contraction and relaxation cycles.
Mutations in this gene cause Darier-White disease (keratosis follicularis), an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization.
Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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