Thermo Fisher Scientific CD7 Polyclonal Antibody
CD7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, IHC, Flow Cytometry, ELISA에 적합. 인간, 마우스, 랫트 반응성. Protein A로 정제된 액상 항체이며, 안정적인 -20°C 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CD7 (amino acids 181–240) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.
The N-terminal amino acids (1–107) are homologous to Ig kappa-L chains, while the C-terminal region is proline-rich and likely forms a stalk supporting the Ig domain.
CD7 is expressed on immature and mature T-lymphocytes, T cell leukemia cells, natural killer cells, and a subset of normal and malignant B cells.
Cross-linking of CD7 modulates T cell and NK cell activity, influencing calcium flux, adhesion molecule expression, cytokine secretion, and proliferation.
CD7 associates with phosphoinositol 3'-kinase, and its ligation induces D-3 phosphoinositide production and tyrosine phosphorylation.
Expression of CD7 serves as an important marker in leukemia diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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