Thermo Fisher Scientific PCDHA2 Polyclonal Antibody
Human PCDHA2 단백질에 특이적인 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 용액 형태로 제공. 뇌 내 세포 간 결합 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PCDHA2. Recombinant protein control fragment (Product # RP-96997) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645257 |
Product Specific Information
- Immunogen sequence: PSLSQGPDSA EEKQLSESEY VGKVS
- Highest antigen sequence identity:
- Mouse: 65%
- Rat: 62%
Target Information
The PCDHA2 gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five. This cluster shows a genomic organization similar to B-cell and T-cell receptor gene clusters.
The alpha gene cluster comprises 15 cadherin superfamily genes, including 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons (variable exons) is followed by shared C-terminal exons (constant exons).
Each large N-terminal exon encodes six cadherin ectodomains, while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are plasma membrane proteins likely critical for establishing and maintaining specific cell-cell connections in the brain.
Alternative splicing has been observed, and additional variants have been suggested, though their full-length nature remains undetermined.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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