
Thermo Fisher Scientific Phospho-HMGCR (Ser872) Polyclonal Antibody
Phospho-HMGCR (Ser872) 폴리클로날 항체로, 인간, 마우스, 랫트 시료에서 인산화된 HMGCR 단백질 검출에 적합. WB, IHC, ICC, Flow, ELISA 등 다양한 응용 가능. Protein A로 정제된 고순도 항체로, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human HMGCR around the phosphorylation site of Ser872 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, essential for the biosynthesis of cholesterol and other isoprenoids.
HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in cholesterol production.
Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs used to lower cholesterol levels and reduce cardiovascular disease risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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