Thermo Fisher Scientific Cdc7 Polyclonal Antibody
Human CDC7 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 세포주기 G1/S 전이 연구 및 DNA 복제 개시 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CDC7. Recombinant protein control fragment (Product #RP-96528). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790448 |
Product Specific Information
Immunogen sequence:
ATAQLQVGPE EKIALKHLIP TSHPIRIAAE LQCLTVAGGQ DNVMGVKYCF RKNDHVVIAM PYLEHESFLD ILNSLSFQEV REY
Target Information
CDC7 is a cell division cycle 7 homolog protein that is critical for the G1/S transition and is essential for initiation of DNA replication during cell division. CDC7 is expressed in many normal tissues, but overexpression may be associated with neoplastic transformation in some tumors and transformed cell lines.
CDC7/DBF4 kinase promotes S phase progression by alleviating inhibitory activity in Mcm4. The gene encodes a cell division cycle protein with kinase activity vital for the G1/S transition. Multiple alternatively spliced transcript variants encoding the same protein have been detected.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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