Thermo Fisher Scientific MAPK8IP1 Polyclonal Antibody
MAPK8IP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC, ELISA 등 다양한 응용에 적합하며, Human, Mouse, Rat 반응성. 고순도 Protein A 정제 및 안정적 액상 형태로 제공.
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Thermo Fisher Scientific MAPK8IP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human JIP1/MAPK8IP1 (amino acids 425–524) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene regulates pancreatic beta-cell function and is highly similar to JIP-1, a mouse protein that modulates c-Jun N-terminal kinase (MAPK8). It prevents MAPK8-mediated activation of transcription factors and reduces IL-1 beta and MEKK1-induced apoptosis in pancreatic beta cells. Additionally, it acts as a DNA-binding transactivator of the glucose transporter GLUT2. REST is known to repress this gene in insulin-secreting beta cells. Mutations in this gene have been associated with type 2 diabetes susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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