Thermo Fisher Scientific CSNK1A1L Polyclonal Antibody
CSNK1A1L 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 적합하며, Human, Mouse, Rat 시료에 반응. 고순도 친화 크로마토그래피 정제, PBS/glycerol 버퍼에 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CSNK1A1L (Accession Q8N752), corresponding to amino acid residues K302–N337. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900081 |
Product Specific Information
This antibody detects endogenous levels of total KC1AL.
Target Information
CSNK1A1L (Casein kinase I alpha-like, serine/threonine kinase) dynamically associates with the CBM complex upon T cell receptor engagement to participate in cytokine production and lymphocyte proliferation. It also promotes phosphorylation and inactivation of CARMA1, governing antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. These kinases preferentially utilize acidic proteins such as caseins as substrates and can phosphorylate multiple proteins including CTNNB1, PER1, and PER2. CSNK1A1 also participates in Wnt signaling and may play roles in chromosome segregation during mitosis and cytoskeleton disassembly regulating epithelial cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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