Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI11H9), TrueMAB
Human reactive monoclonal antibody targeting Beta-catenin (CTNNB1). Validated for Western blot and flow cytometry. High purity, liquid form with 0.58 mg/mL concentration. Suitable for research use in cell adhesion and signaling studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11H9 |
| Immunogen | Full-length human recombinant protein of CTNNB1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.58 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and signaling. It interacts with E-cadherin and alpha-catenin to anchor the E-cadherin complex to the actin cytoskeleton. Beta-catenin also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and participates in Wnt/Wingless signaling pathways. These interactions regulate morphogenesis and cell proliferation.
Beta-catenin is expressed in various hair follicle cell types and epithelial tissues. Dysregulation of beta-catenin is linked to diseases such as pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other solid tumors. In the nucleus, beta-catenin coactivates Lef/Tcf transcription factors, promoting transcription of genes like cyclin D and c-myc that drive cell proliferation, contributing to tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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