Thermo Fisher Scientific IGLV6-57 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 27-117. Recombinant protein control fragment (Product #RP-109981). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IGLV6-57,uniProtId:P01721-1,ncbiNodeId:9606,antigenRange:27-117,antigenLength:117,antigenImageFileName:PA5-144743_IGLV6-57_P01721-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144743_IGLV6-57_P01721-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092272

Product Specific Information

Immunogen sequence: HSVSESPGKT VTISCTRSSG SIASNYVQWY QQRPGSAPTT VIYEDNQRPS GVPDRFSGSI DSSSNSASLT ISGLKTEDEA DYYCQSYDSS NHTVL

Antigen sequence identity: Mouse 47%; Rat 65%

Target Information

IGLV6-57 (Immunoglobulin Lambda Variable 6-57) is a Protein Coding gene. An important paralog of this gene is IGLV1-40. V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.