Thermo Fisher Scientific TMEM119 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested dilution: 정보 없음
• View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested dilution: 1:500–1:1,000
• View publication

Immunocytochemistry (ICC/IF)

• Tested dilution: 정보 없음
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Product Specifications

Product Specific Information

• Immunogen sequence:
  GDGARMVEGR GAEEEEKGSQ EGDQEVQGHG VPVETPEAQE EPCSGVLEGA VVAGEGQGEL EGSLLLAQEA QGPVGPPESP CACSSVHPS
• Highest antigen sequence identity:
  • Mouse: 52%
  • Rat: 46%

Target Information

Tmem119 encodes a single-pass type I transmembrane protein interacting with various micro-RNAs and transcription factors such as SMAD1, SMAD5, and RUNX2. It serves as a reliable surface marker of microglia, distinguishing them from infiltrating macrophages. Microglia, restricted to the brain, are involved in debris clearance and neuronal pruning, exhibiting neuroprotective and neurotoxic functions depending on their environment. Reactive microglia co-express Iba1 and are implicated in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and Multiple Sclerosis. Outside the neural system, Tmem119 is associated with osteoblast differentiation and ossification.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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