Thermo Fisher Scientific E-cadherin Monoclonal Antibody (67A4), PE
E-cadherin 단백질을 인식하는 PE-conjugated mouse monoclonal antibody로, 세포 간 접착 및 암 전이 연구에 적합. Flow cytometry에 최적화되어 있으며, 4°C 암소 보관 필요. Human 시료에 반응하며, 형광 파장은 565/576 nm.
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Applications
- Flow Cytometry (Flow): 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 67A4 |
| Immunogen | T-47D cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, Do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534563 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD324 / E-cadherin, an approximately 100 kDa epithelial cell adhesion molecule. Detection of E-cadherin is important for determining the invasive potential of epithelial neoplasms.
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in the CDH1 gene (chromosome 16) are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function contributes to tumor progression by enhancing proliferation, invasion, and metastasis.
E-cadherin also mediates bacterial adhesion to mammalian cells and is essential for maintaining epithelial tissue integrity and architecture.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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