Thermo Fisher Scientific MUC4 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MUC4 protein. Validated for IHC (paraffin) with dilution 1:100–1:1,000. Supplied as liquid, 1 mg/mL in PBS with 20% glycerol. Useful for studying mucin expression and cancer biomarker research.
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Applications
Tested Applications and Dilutions
| Application | Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 1914–2064 of Human Mucin 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544743 |
Product Specific Information
- Recommended positive control: A549 cells
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Mucin 4 (MUC4) is a membrane-bound mucin transmembrane glycoprotein that protects and lubricates nearly all mucosal surfaces, including bronchioles, corneas, and reproductive tracts.
Abnormal MUC4 expression is observed in various carcinomas and sarcomas, such as fibromyoxoid sarcoma and pancreatic adenocarcinoma.
Immunohistochemical detection of MUC4 is being studied as a potential biomarker for these cancers.
MUC4 mutations have been associated with certain population-specific conditions, including infertility and endometriosis in Taiwanese individuals and gallstone formation in Chinese men.
Because of its key role in mucosal protection, MUC4 dysfunction is often linked to metastatic cancer invasion.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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