Thermo Fisher Scientific CK2 alpha-2 Polyclonal Antibody
Thermo Fisher Scientific의 CK2 alpha-2 폴리클로날 항체는 인간 CSNK2A2의 C-말단 영역을 표적으로 하는 고품질 연구용 항체입니다. Western blot 및 immunoprecipitation에 적합하며, 높은 종 간 상동성을 보입니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunoprecipitation (IP) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal region of human CSNK2A2 (aa 301–350) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2884530 |
Product Specific Information
Immunogen sequence:
LLDKLLRYDH QQRLTAKEAM EHPYFYPVVK EQSQPCADNA VLSSGLTAARStorage recommendations:
- Short term: 2–8°C, up to 1 week
- Long term: -20°C in small aliquots to prevent freeze-thaw cycles
Predicted homology:
Cow: 100%
Dog: 100%
Guinea Pig: 93%
Horse: 100%
Human: 100%
Mouse: 86%
Pig: 100%
Rabbit: 100%
Rat: 86%
Yeast: 92%
Target Information
Casein kinase II (CK2) is a serine/threonine protein kinase present in all eukaryotic cells and plays a fundamental role in cellular functions. The holoenzyme is a tetramer composed of two catalytic alpha or alpha-prime subunits and two regulatory beta subunits. The alpha subunit serves as the catalytic unit, while the beta subunit’s function remains unclear.
CK2 phosphorylates key intracellular signaling proteins involved in tumor suppression (p53, PTEN) and tumorigenesis (myc, jun, NF-κB). It also influences Wnt signaling via β-catenin phosphorylation and the PI3K/Akt pathway.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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