Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI1A9)
Human PIK3C2A 단백질(aa 230-560)을 인식하는 Mouse IgG2a 단클론 항체로, Western blot에 적합. 액상 형태로 제공되며, 고순도 친화 크로마토그래피 정제. -20°C 보관, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 230–560 of PIK3C2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725023 |
Target Information
Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as Class I PI3 kinases, Class II enzymes are linked to receptor-mediated processes such as insulin signaling, neuronal survival, and growth factor signaling. PI3-kinases play roles in pathways involved in cell proliferation, oncogenic transformation, survival, migration, and intracellular trafficking.
PIK3C2A contains a lipid kinase catalytic domain and a C-terminal C2 domain, characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate membrane translocation and protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of wortmanin. It can be activated by insulin and may be involved in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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