Thermo Fisher Scientific DTL Recombinant Rabbit Monoclonal Antibody (23GB5230)
DTL 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot에 최적화됨. 인간, 생쥐, 랫트 반응성. HEK293F 발현 시스템 사용, 액상 형태로 제공. 세포 주기 조절 및 DNA 손상 반응 연구에 적합.
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Thermo Fisher Scientific DTL Recombinant Rabbit Monoclonal Antibody (23GB5230)
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000–1:5,000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB5230 |
| Immunogen | A synthesized peptide derived from human CDT2 (50–200 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response, and translesion DNA synthesis.
The DCX(DTL) complex, also known as CRL4(CDT2) complex, mediates polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1).
CDT1 degradation in response to DNA damage ensures proper cell cycle regulation of DNA replication.
CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing.
Most substrates require interaction with PCNA for polyubiquitination via their PIP-box; those containing the K+4 motif recruit the DCX(DTL) complex, leading to degradation.
In undamaged proliferating cells, the DCX(DTL) complex promotes Lys-164 monoubiquitination of PCNA, contributing to PCNA-dependent translesion DNA synthesis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(이미지 파일: MA5-52820_DTL_Q9NZJ0-1_Rabbit.svg, MA5-52820_DTL_Q9NZJ0-1_Rabbit_PDP.jpeg)
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