Thermo Fisher Scientific CD38 Monoclonal Antibody (HIT2), PE-Texas Red

Applications

• Flow Cytometry (Flow): Assay-dependent
• View 11 publications

Product Specifications

Additional Formats

• APC
• APC-Cyanine5.5
• FITC
• PE
• Qdot 655
• Request custom conjugation

Product Specific Information

The R-phycoerythrin (PE)-Texas Red conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source — the 488 nm line of the argon-ion laser.

Target Information

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD+ glycohydrolase or as a cell surface receptor.

Antibodies to CD38 are useful for:

• Subtyping of lymphomas and leukemias
• Detection of plasma cells (e.g., identification of myelomas)
• Marker for activated B and T cells

CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is highly expressed in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.

Analyte Specific Reagent

제품 이미지