Thermo Fisher Scientific CD38 Monoclonal Antibody (HIT2), PE-Texas Red
인간 CD38 단백질을 인식하는 마우스 단클론 항체로 PE-Texas Red로 결합되어 다중 형광 분석에 적합합니다. Flow Cytometry에 사용 가능하며, 488 nm 레이저로 여기됩니다. 4℃에서 어둠 속 보관하며, PBS-BSA 완충액에 보관됩니다.
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Applications
- Flow Cytometry (Flow): Assay-dependent
- View 11 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIT2 |
| Immunogen | Human CD38 |
| Conjugate | PE-Texas Red |
| Excitation / Emission Max | 567 / 615 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with BSA, sucrose |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10392545 |
Additional Formats
Product Specific Information
The R-phycoerythrin (PE)-Texas Red conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source — the 488 nm line of the argon-ion laser.
Target Information
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD+ glycohydrolase or as a cell surface receptor.
Antibodies to CD38 are useful for:
- Subtyping of lymphomas and leukemias
- Detection of plasma cells (e.g., identification of myelomas)
- Marker for activated B and T cells
CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is highly expressed in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
Analyte Specific Reagent
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