Thermo Fisher Scientific SLC30A8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 315-369. Recombinant protein control fragment (Product #RP-108278). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SLC30A8,uniProtId:Q8IWU4-1,ncbiNodeId:9606,antigenRange:315-369,antigenLength:369,antigenImageFileName:PA5-144933_SLC30A8_Q8IWU4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144933_SLC30A8_Q8IWU4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092048

Product Specific Information

Immunogen sequence: LSAHVATAAS RDSQVVRREI AKALSKSFTM HSLTIQMESP VDQDPDCLFC EDPCD

Antigen sequence identity: Mouse 73%; Rat 73%

Target Information

Slc30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of Slc30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes, but no genetic association has been found with Type 1 diabetes. Slc30A8 expression in b-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1 beta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.