Thermo Fisher Scientific GRAMD1A Monoclonal Antibody (1-E4)
GRAMD1A 단백질을 표적하는 Thermo Fisher Scientific의 Mouse IgM 단클론 항체. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 콜레스테롤 수송 및 자가포식 관련 연구에 활용 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:400 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1-E4 |
| Immunogen | Recombinant protein within Human GRAMD1A aa 1–724 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 40% Glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802519 |
Target Information
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). It contains unique domains for binding cholesterol and the PM, serving as a molecular bridge for cholesterol transfer between PM and ER. Plays a crucial role in cholesterol homeostasis and can localize to the PM depending on membrane cholesterol levels.
In lipid-poor conditions, it localizes to the ER membrane, and in response to excess cholesterol in the PM, it is recruited to endoplasmic reticulum–plasma membrane contact sites (EPCS) mediated by the GRAM domain. At the EPCS, the sterol-binding VASt/ASTER domain binds cholesterol in the PM and facilitates its transfer to the ER.
May play a role in tumor progression and autophagy regulation, being required for autophagosome biogenesis. This autophagy function depends on its cholesterol-transfer activity. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-32884_GRAMD1A_Q96CP6-1_House_mouse.svg, MA5-32884_GRAMD1A_Q96CP6-1_House_mouse_PDP.jpeg)
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