Thermo Fisher Scientific GRAMD1A Monoclonal Antibody (1-E4)

Applications and Tested Dilution

Product Specifications

Target Information

Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). It contains unique domains for binding cholesterol and the PM, serving as a molecular bridge for cholesterol transfer between PM and ER. Plays a crucial role in cholesterol homeostasis and can localize to the PM depending on membrane cholesterol levels.
In lipid-poor conditions, it localizes to the ER membrane, and in response to excess cholesterol in the PM, it is recruited to endoplasmic reticulum–plasma membrane contact sites (EPCS) mediated by the GRAM domain. At the EPCS, the sterol-binding VASt/ASTER domain binds cholesterol in the PM and facilitates its transfer to the ER.
May play a role in tumor progression and autophagy regulation, being required for autophagosome biogenesis. This autophagy function depends on its cholesterol-transfer activity. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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