Thermo Fisher Scientific IL1R2 Recombinant Rabbit Monoclonal Antibody (161)

Applications

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Rat IL-1R2/CD121b.

Target Information

The protein encoded by this gene is a cytokine receptor belonging to the interleukin 1 receptor family. It binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor type I (IL1R1/IL1RA), acting as a decoy receptor that inhibits ligand activity. Interleukin 4 (IL4) antagonizes interleukin 1 activity by inducing expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.