Thermo Fisher Scientific UNG Monoclonal Antibody (OTI1G2)
Thermo Fisher Scientific의 UNG 단클론 항체(OTI1G2)는 Human 및 비인간 영장류 시료에 반응하며, Western blot과 IHC(Paraffin)에 최적화되어 있습니다. HEK293T 세포에서 발현된 full-length UNG 단백질로부터 제작되었으며, 액상 형태로 안정적 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G2 |
| Immunogen | Full-length human recombinant protein of UNG produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725630 |
Target Information
The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These isoforms are generated by alternative splicing and two differentially regulated promoters (PA and PB). The cDNAs for UNG1 and UNG2 are similar in size (2061 and 2058 bp), thus not separated as distinct species in gel electrophoresis.
Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids at the N-terminal region, which is not required for catalytic activity. The major function of UNG gene products is to repair mutagenic U:G mispairs caused by cytosine deamination. For example, UNG2 removes misincorporated dUMP residues.
Expression levels of UNG1 and UNG2 vary by cell and tissue type and are cell cycle-regulated, showing higher expression in proliferating cells. UNG1 is a 304 amino acid protein, and UNG2 is a 313 amino acid protein.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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