Thermo Fisher Scientific WASP Polyclonal Antibody
WASP 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, 인간 시료에 반응하며 IHC, ICC/IF, Flow Cytometry에 사용 가능. 고순도(암모늄 황산 침전)로 정제된 액상 형태이며, TBS 버퍼(pH 7.3, 0.5% BSA) 내 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (SPADKKRSGKKKI) corresponding to internal amino acids of WAS (aa 221–234) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10988859 |
Product Specific Information
- This antibody is predicted to react with canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
The Wiskott-Aldrich syndrome family of proteins share similar domain structures and are involved in transduction of signals from cell surface receptors to the actin cytoskeleton.
These proteins are regulated by multiple stimuli and interact with various proteins, including the small GTPase Cdc42 and the Arp2/3 complex.
Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease caused by mutations in the WAS gene, leading to immune dysregulation and microthrombocytopenia.
The WAS gene product is a cytoplasmic protein expressed exclusively in hematopoietic cells, which exhibit signaling and cytoskeletal abnormalities in affected patients.
A transcript variant with an alternative promoter and distinct 5’ UTR sequence has been described, though its full-length nature remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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