Thermo Fisher Scientific GLE1 Polyclonal Antibody
GLE1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. WB, IHC, ICC/IF, IP 등 다양한 응용에 적합하며, 고순도 Protein G 정제 방식으로 제조되었습니다. 인체 반응성, 액상 형태, 안정적 보관(-20°C) 가능.
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Thermo Fisher Scientific GLE1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (IHC) | 1:20–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:200–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Nucleoporin GLE1 protein (141–380aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.62 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2902293 |
Product Specific Information
This antibody has been tested in direct ELISA.
Target Information
The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and, in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus.
Mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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