Thermo Fisher Scientific CD150 Recombinant Rabbit Monoclonal Antibody (110)

Applications

ELISA

• Tested Dilution: 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to large rabbit immune repertoire

This antibody has specificity for Human CD150/SLAM/SLAMF1.

Target Information

CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily and plays a role in T cell stimulation. SLAM is expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a subset of B cells. It is rapidly induced on naive T cells after activation.
Activated B cells express membrane-bound, soluble, and cytoplasmic isoforms of SLAM. Homophilic SLAM-SLAM interactions enhance B cell activation and differentiation.
The extracellular domain of CD150 serves as a receptor for the measles virus and acts as a co-activator on T and B cells. CD150 interacts with SH2D1A and PTPN11 via its cytoplasmic domain. Mutations in the CD150 gene may be associated with X-linked lymphoproliferative disease (XLP).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.