Thermo Fisher Scientific NMDAR3A/NMDAR3B Monoclonal Antibody (K35/40.1)
NMDAR3A/NMDAR3B 단백질 검출용 마우스 단클론 항체로, Western blot 및 면역침전 실험에 적합합니다. NR1 및 NR2A-D와 교차반응이 없으며, Protein G로 정제된 액상 형태입니다. 인간, 마우스, 랫트 시료에서 반응합니다.
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Applications
- Western Blot (WB): 1–10 µg/mL
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K35/40.1 |
| Immunogen | Fusion protein of NR3A amino acids 780–914 from the extracellular III–IV loop |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2232559 |
Product Specific Information
MA1-10881 detects Glutamate NMDA Receptor NR3A/B subunits from human, mouse, and rat samples.
This antibody does not cross-react with NR1 or NR2A-D subunits.
It has been successfully used in Western blot and immunoprecipitation applications.
Immunogen: Fusion protein of NR3A amino acids 780–914 from the extracellular III–IV loop.
Target Information
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels characterized by:
- Reduced single-channel conductance
- Low calcium permeability
- Low voltage-dependent sensitivity to magnesium
Grin3a is glycine-mediated and may play a role in dendritic spine development and PPP2CB–NMDAR mediated signaling.
It belongs to the superfamily of glutamate-regulated ion channels, functioning in both physiological and pathological processes in the CNS.
Grin3a shows >90% identity with the corresponding rat subunit.
Knockout mouse studies suggest involvement in synaptic element development via modulation of NMDA receptor activity.
Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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