Thermo Fisher Scientific NMDAR3A/NMDAR3B Monoclonal Antibody (K35/40.1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-10 µg/mL

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

K35/40.1

Immunogen

Fusion protein of NR3A amino acids 780-914 from the extracellular III-IV loop.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.4 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2232559

Product Specific Information

MA1-10881 detects Glutamate NMDA Receptor NR3A/B Subunit from human, mouse, and rat samples. This antibody does not cross-react with subunits NR1 or NR2A-D.

MA1-10881 has been successfully used in Western blot and immunoprecipitation applications.

The MA1-10881 immunogen is Fusion protein of NR3A amino acids 780-914 from the extracellular III-IV loop.

Target Information

Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Grin3a is mediated by glycine and may play a role in the development of dendritic spines. Further, Grin3a may play a role in PPP2CB-NMDAR mediated signaling mechanism. Grin3a belongs to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in Grin3a suggest that the protein may be involved in the development of synaptic elements by modulating NMDA receptor activity. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.