Thermo Fisher Scientific PHLPP1 Polyclonal Antibody
PHLPP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. 인간 시료에 반응하며 IHC(P)에서 사용 가능합니다. 액상 형태로 2.1 mg/mL 농도, 항원 친화 크로마토그래피로 정제됨. -20°C에서 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human PH domain and leucine-rich repeat protein phosphatase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635928 |
Product Specific Information
This antibody detects endogenous levels of total PHLPP1 protein.
Target Information
PHLPP1 is a member of the serine/threonine phosphatase family, which regulates Akt kinases (AKT1, AKT2, AKT3) and PKC isoforms.
PHLPP1 and PHLPP2 share similar domain structures and dephosphorylate distinct Akt isoforms at Serine473, a critical activation site.
PHLPP1 specifically targets AKT2 and AKT3, promoting apoptosis and potentially acting as a tumor suppressor.
Elevated PHLPP1 expression may contribute to obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-50475_PHLPP1_O60346-1_Rabbit.svg, PA5-50475_PHLPP1_O60346-1_Rabbit_PDP.jpeg)
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