Thermo Fisher Scientific ATMIN Polyclonal Antibody
Human ATMIN 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:500~1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 버퍼에 보관. DNA 손상 반응 및 발달 연구용으로 적합.
- 카탈로그번호
- PA564295
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ATMIN. Recombinant protein control fragment (Product # RP-103644) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2638337 |
Product Specific Information
Immunogen sequence:
TFRCTCGCPY ASRTALQSHI YRTGHEIPAE HRDPPSKKRK MENCAQNQKL SNKTIESLNN QPIPRPDTQE LEASEIKLEP SFEDSCGSNT D
Sequence identity:
- Mouse: 71%
- Rat: 71%
Target Information
The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51.
ATMIN is thought to be involved in embryonic development, as its absence causes late-embryonic lethality in mice with multiple organ development defects.
It also activates transcription of DYNLL1, a light chain of the dynein motor complex and regulator of protein dimerization.
DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a feedback loop regulating DYNLL1 expression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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