Thermo Fisher Scientific LAMTOR4 Polyclonal Antibody
LAMTOR4 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 인간과 랫트 반응성이 있으며, 고순도 친화 크로마토그래피 정제 제품입니다. 액상 형태로 −20°C 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LAMTOR4 (Accession Q0VGL1), corresponding to amino acid residues E10–N60 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899559 |
Product Specific Information
Antibody detects endogenous levels of total C7orf59.
Target Information
LAMTOR4 is part of the Ragulator complex and is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.
LAMTOR4 is activated by amino acids through a mechanism involving the lysosomal V-ATPase. The Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag.
LAMTOR4, Ragulator, and Rag GTPases act as a scaffold recruiting mTORC1 to lysosomes where it is subsequently activated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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