Thermo Fisher Scientific Influenza A H1N1 M1 (A/Puerto Rico/8/34/Mount Sinai) Monoclonal Antibody (02)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1/Matrix Protein 1.

Target Information

The M1 protein plays critical roles in virus replication, including entry, uncoating, assembly, and budding. M1 binding to ribonucleocapsids (RNPs) in the nucleus may inhibit viral transcription. Interaction of viral NEP with M1-RNP promotes nuclear export of the complex to the virion assembly site at the apical plasma membrane in polarized epithelial cells.
M1 interacts with NA and HA to associate with lipid rafts, forming a continuous shell on the inner side of the virion lipid bilayer where it binds RNP. During viral entry, the M2 ion channel acidifies the virion core, inducing M1 dissociation from RNPs, which are then transported to the nucleus for transcription and replication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.