Thermo Fisher Scientific PTPN6/SHP1 Polyclonal Antibody
PTPN6/SHP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB 및 IP에 사용 가능하며, 비결합형 액상 형태로 제공. 인간 유래 항원(545–595 aa)을 기반으로 제작되어 혈액세포 내 SHP-1 연구에 적합.
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Thermo Fisher Scientific PTPN6/SHP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 545 to 595 of Human Tyrosine-protein phosphatase non-receptor type 6 (SHP-1, UniProt ID: P29350-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase primarily expressed in hematopoietic cells. It contains two SH2 domains, a catalytic domain, and a regulatory carboxy-terminal domain. SHP-1 downregulates multiple tyrosine kinase-regulated pathways by dephosphorylating target proteins.
In hematopoietic cells, SHP-1 binds phosphorylated erythropoietin receptors (EpoR) to negatively regulate growth. Overexpression in epithelial cells leads to dephosphorylation of Ros receptor tyrosine kinase, reducing Ros-dependent proliferation.
In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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