Thermo Fisher Scientific ZNRF1 Polyclonal Antibody
ZNRF1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 다클론 항체. Western blot 및 IHC(P)에서 사용 가능하며 인간과 마우스 반응성을 가짐. 신경세포 분화 및 신경전달 유지 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-SDSTYAHGNGYQET, from the internal region of mouse Znrf1 (aa 93–107) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2554586 |
Product Specific Information
This antibody is predicted to react with human, rat, dog, pig, and cow based on sequence homology.
It has been tested in Peptide ELISA with an antibody detection limit dilution of 1:32,000.
Target Information
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, playing a role in neuronal cell differentiation. It contributes to the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cell differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration through Lys-48-linked polyubiquitination and subsequent degradation of AKT1 in axons, preventing AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2, followed by destabilization of microtubule assembly in axons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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