Thermo Fisher Scientific TIN2 Polyclonal Antibody
Human TIN2 단백질을 인식하는 Rabbit polyclonal antibody로 Western blot에 최적화됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 민감도를 제공. PBS 기반 저장용액에 포함되어 장기 보관 가능. 연구용으로만 사용.
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Thermo Fisher Scientific TIN2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human TIN2 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736705 |
Product Specific Information
- Positive Control: IMR32 whole cell extract, 30 µg IMR32 nuclear extract
- Predicted Reactivity: Chimpanzee (99%), Bovine (80%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TRF1 is a negative regulator of telomere length maintenance. Two proteins, tankyrase and Tin2, which bind to mammalian TRF1, have been identified.
Tankyrase localizes to telomeres by binding TRF1 through its ankyrin repeats and exhibits PARP activity, functioning as acceptors for ADP-ribosylation.
ADP-ribosylation of TRF1 diminishes its ability to bind telomeric DNA, suggesting telomere function is regulated by poly(ADP)-ribosylation.
TIN2 protein interacts with TRF1, localizes to telomeres, and is essential for proper regulation of telomere length.
TIN2 and TRF1 are constitutively expressed and act together to counterbalance telomere elongation by telomerase, though endogenous expression levels are low and may be difficult to visualize by immunostaining.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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