Thermo Fisher Scientific DAPK3 Polyclonal Antibody
DAPK3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 고순도 Protein A 정제, 1 mg/mL 농도, Human 반응성. 세포 사멸 및 신호전달 연구에 적합.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human DAPK3, amino acids 30–130 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DAPK3 (Death-associated protein kinase 3) is a serine/threonine kinase involved in cell motility, smooth muscle contractility, and cell death processes. It is encoded by ZIPK and forms part of desmosomes and the epidermal cornified envelope in keratinocytes.
The N-terminal domain interacts with the plasma membrane, while the C-terminal domain associates with intermediate filaments. Through its rod domain, DAPK3 forms complexes with envoplakin, potentially linking the cornified envelope, desmosomes, and intermediate filaments.
AKT1/PKB, a kinase involved in cell growth and survival signaling, interacts with DAPK3, suggesting a role in AKT1-mediated signaling localization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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