Thermo Fisher Scientific SPO11 Polyclonal Antibody, MaxPab

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Protein Sequence:

MAFAPMGPEA SFFDVLDRHR ESLLAALRRG GREPPTGGSR LASRFEDSVG LQMVSHCTTR 
KIKSDSPKSA QKFSLILKIL SMIYKLVQSN TYATKRDIYY TDSQLFGNQT VVDNIINDIS 
CMLKVSRRSL HILSTSKGLI AGNLRYIEED GTKVNCTCGA TAVAVPSNIQ GIRNLVTDAK 
FVLIVEKDAT FQRLLDDNFC NKLSPCIMIT GKGVPDLNTR LLVKKLWDTF HVPVFTLVDA 
DPHGIEIMCI YKYGSMSMSF EAHHLTVPAI RWLGLLPSDL KRLNVPKDSL IPLTKRDQMK 
LDSILRRPYV TCQPFWRKEM EIMADSKMKA EIQALTFLSS DYLSRVYLPN KLKFGGWI

Target Information

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently linked to the 5′ end of DSBs and is essential for their formation. The human SPO11 protein shares sequence similarity and conserved features with the yeast meiotic recombination protein and belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been identified, though only two full-length forms are well characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.