Thermo Fisher Scientific CABYR Polyclonal Antibody
CABYR 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간 시료 반응성이 있으며, 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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Thermo Fisher Scientific CABYR Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CABYR. Recombinant protein control fragment (Product #RP-98249). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639213 |
Product Specific Information
Immunogen sequence:
YNDVPVTEGV VYIEQLPEQI VIPFTDQVAC LKENEQSKEN EQSPRVSPKS VVEKTTSGMS KKSVESVKLA QLEENAKYSS VYMEAEATAL LSD
Highest antigen sequence identity to orthologs:
- Mouse: 58%
- Rat: 56%
Target Information
Spermatozoa gain fertilization capacitation and hyperactivation after residing in the uterus or oviduct. Calcium, cAMP, and protein tyrosine phosphorylation are necessary for the molecular mechanisms that allow for this transformation.
CABYR (Calcium-binding tyrosine phosphorylation-regulated protein), also known as Fibrousheathin-2 or Cancer/testis antigen 88, is a 493 amino acid protein expressed in sperm flagella and exhibits increased tyrosine phosphorylation during capacitation.
There are six named isoforms of CABYR produced by alternative splicing events:
- Isoform 1: expressed in testis
- Isoform 3 and 5: expressed in pancreas, brain, and various brain tumors
- Isoforms 1, 2, and 6: likely bind calcium
- Isoforms 3, 4, and 5: probably do not bind calcium
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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