Thermo Fisher Scientific SURF1 Polyclonal Antibody
SURF1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인체, 생쥐, 랫트 시료에 반응하며, 액상 형태로 제공됩니다. 복합체 IV 연구 및 미토콘드리아 기능 분석에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SURF1 (Accession Q15526), corresponding to amino acid residues Y161–E211 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2854170 |
Product Specific Information
Antibody detects endogenous levels of total SURF1.
Target Information
The SURF-1 protein plays a vital role in the assembly of complex IV (CIV or COX) of the mitochondrial respiratory chain. It is expressed in the inner mitochondrial membrane, and mutations in the SURF-1 gene cause cytochrome c oxidase complex IV deficiency. This deficiency leads to Leigh syndrome, a severe neurological disorder characterized by necrotic lesions in subcortical brain regions. SURF-1 mutations are associated with high embryonic lethality and early postnatal mortality, as well as deficits in muscle strength and motor performance. Morphological abnormalities in heart, brain, and skeletal muscle are frequently observed due to SURF-1 mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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