Thermo Fisher Scientific B2M Monoclonal Antibody (OTI1A7), TrueMAB
Human B2M 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC(P), ELISA에 적합합니다. TrueMAB 형식으로 제작되었으며, 고순도 Affinity Chromatography 정제. -20°C 보관, 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 21–119 of human B2M produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the major histocompatibility complex (MHC) class I. It is associated with HLA Class I antigens and expressed on various cell types, including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes. B2M is also present in free form in plasma. The sequence is homologous to immunoglobulin constant regions, primarily forming a beta-pleated sheet structure. It participates in antigen processing and presentation, TCR signaling, and downstream signaling in naive CD8+ cells. The B2M gene is located on chromosome 15, and mutations can lead to hypercatabolic hypoproteinemia. B2M levels are useful for monitoring renal function and serve as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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