ELK Biotechnology Kv1.3 (phospho Tyr187) rabbit pAb

Kv1.3 (phospho Tyr187) rabbit pAb

제품 개요

Kv1.3 (phospho Tyr187) rabbit pAb는 인산화된 Tyr187 부위를 인식하도록 제작된 토끼 폴리클로날 항체입니다. 세포막에 위치한 전압 개폐성 칼륨 채널 Kv1.3 단백질의 검출 및 기능 연구에 활용됩니다.

제품 정보

Background

Potassium channels represent one of the most complex classes of voltage-gated ion channels, both functionally and structurally. They regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes—shaker, shaw, shab, and shal—have been identified in Drosophila, each with human homologs.
This gene encodes a member of the voltage-gated, shaker-related potassium channel subfamily. It contains six membrane-spanning domains with a shaker-type repeat in the fourth segment and belongs to the delayed rectifier class, enabling efficient neuronal repolarization after an action potential. Kv1.3 plays an essential role in T-cell proliferation.