ELK Biotechnology Kv1.3 (phospho Tyr187) rabbit pAb
Kv1.3 (phospho Tyr187) rabbit pAb는 인산화된 Kv1.3 단백질을 특이적으로 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며 세포막 단백질 연구에 활용됩니다. 인간, 마우스, 랫트 시료에 반응합니다.
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Kv1.3 (phospho Tyr187) rabbit pAb
제품 개요
Kv1.3 (phospho Tyr187) rabbit pAb는 인산화된 Tyr187 부위를 인식하도록 제작된 토끼 폴리클로날 항체입니다. 세포막에 위치한 전압 개폐성 칼륨 채널 Kv1.3 단백질의 검출 및 기능 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Kv1.3 (phospho Tyr187) rabbit pAb |
| Alternative Names | KCNA3; HGK5; Potassium voltage-gated channel subfamily A member 3; HGK5; HLK3; HPCN3; Voltage-gated K(+) channel HuKIII; Voltage-gated potassium channel subunit Kv1.3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Kv1.3/KCNA3 around the phosphorylation site of Tyr135 (AA range: 101–150) |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 58 kD |
| GeneID (Human) | 3738 |
| Human Swiss-Prot No. | P22001 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
Potassium channels represent one of the most complex classes of voltage-gated ion channels, both functionally and structurally. They regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes—shaker, shaw, shab, and shal—have been identified in Drosophila, each with human homologs.
This gene encodes a member of the voltage-gated, shaker-related potassium channel subfamily. It contains six membrane-spanning domains with a shaker-type repeat in the fourth segment and belongs to the delayed rectifier class, enabling efficient neuronal repolarization after an action potential. Kv1.3 plays an essential role in T-cell proliferation.
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