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ELK Biotechnology Integrin β1 rabbit pAb
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Integrin β1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 세포막 단백질 검출에 유용하며, 인간, 마우스, 랫트 시료에 반응합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology ES5949-100UL Integrin β1 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES5949-50UL Integrin β1 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Integrin β1 rabbit pAb
Integrin β1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Integrin β1 rabbit pAb |
| Alternative Names | ITGB1; FNRB; MDF2; MSK12; Integrin beta-1; Fibronectin receptor subunit beta; VLA-4 subunit beta; CD antigen CD29 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Integrin beta1. AA range: 746-795 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 140 kD |
| GeneID (Human) | 3688 |
| Human Swiss-Prot No. | P05556 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
- Cell membrane; Single-pass type I membrane protein
- Cell projection (invadopodium, ruffle, lamellipodium)
- Recycling endosome, melanosome, cleavage furrow
- Cell junction (focal adhesion), cell surface
- Isoform 2 does not localize to focal adhesions
- Highly enriched in stage I melanosomes
- Located on plasma membrane of neuroblastoma NMB7 cells
- In lung cancer cell line: diffuse membrane and vesicular localization during prometaphase/metaphase; concentrated at cleavage furrow during telophase
Background
Integrins are heterodimeric proteins composed of alpha and beta subunits. At least 18 alpha and 8 beta subunits are known in mammals. Integrin family members function as membrane receptors involved in cell adhesion and recognition processes such as embryogenesis, hemostasis, tissue repair, immune response, and tumor metastasis. This gene encodes a beta subunit, and multiple alternatively spliced transcript variants producing different isoforms have been identified (RefSeq, Jul 2008).
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