ELK Biotechnology Integrin β1 (phospho Thr789) rabbit pAb

Integrin β1 (phospho Thr789) rabbit pAb

제품 정보

세포 내 위치 (Cellular Localization)

• Cell membrane; Single-pass type I membrane protein
• Cell projection, invadopodium membrane; Single-pass type I membrane protein
• Cell projection, ruffle membrane; Single-pass type I membrane protein
• Recycling endosome; Melanosome; Cleavage furrow
• Cell projection, lamellipodium; Cell junction, focal adhesion; Cell surface
• Isoform 2 does not localize to focal adhesions
• Highly enriched in stage I melanosomes
• Located on plasma membrane of neuroblastoma NMB7 cells
• In lung cancer cell line, during prometaphase and metaphase, localizes diffusely at membrane and in few intracellular vesicles
• In early telophase, detected mainly on matrix-facing side of cells
• By mid-telophase, concentrated to ingressing cleavage furrow, mainly basal side

Background

Integrins are heterodimeric proteins composed of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in processes such as embryogenesis, hemostasis, tissue repair, immune response, and metastatic diffusion of tumor cells. This gene encodes a beta subunit, and multiple alternatively spliced transcript variants encoding different isoforms have been identified.
(Provided by RefSeq, Jul 2008)

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