ELK Biotechnology Integrin β1 (phospho Tyr795) rabbit pAb

Integrin β1 (phospho Tyr795) rabbit pAb

제품 정보

Cellular Localization

Cell membrane; Single-pass type I membrane protein.
Cell projection, invadopodium membrane; Single-pass type I membrane protein.
Cell projection, ruffle membrane; Single-pass type I membrane protein.
Recycling endosome; Melanosome; Cleavage furrow; Cell projection, lamellipodium; Cell projection, ruffle; Cell junction, focal adhesion; Cell surface.
Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes.
Located on plasma membrane of neuroblastoma NMB7 cells.
In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles.
In early telophase, detected mainly on the matrix-facing side of the cells.
By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal region.

Background

Integrins are heterodimeric proteins composed of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals.
Integrin family members function as membrane receptors involved in cell adhesion and recognition in various processes including embryogenesis, hemostasis, tissue repair, immune response, and metastatic diffusion of tumor cells.
This gene encodes a beta subunit. Multiple alternatively spliced transcript variants encoding different protein isoforms have been identified for this gene (RefSeq, Jul 2008).