ELK Biotechnology AR (phospho Tyr363) rabbit pAb
인산화 Tyr363 부위의 안드로겐 수용체(AR)를 인식하는 rabbit polyclonal antibody. WB 및 ELISA에 적합하며, 사람·마우스·랫트 반응성. 핵과 세포질에서 발현되는 AR 연구용에 유용.
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제품명
AR (phospho Tyr363) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
이 항체는 인간 안드로겐 수용체(Androgen Receptor)의 Tyr363 인산화 부위를 인식하도록 제작된 rabbit polyclonal antibody입니다. 스테로이드 호르몬 활성화 전사인자로 작용하는 AR 단백질의 인산화 상태 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human Androgen Receptor around the phosphorylation site of Tyr363 (AA range: 331–380) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85 kDa |
| GeneID (Human) | 367 |
| Human Swiss-Prot No | P10275 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus, Cytoplasm. Detected at promoter regions of target genes. Predominantly cytoplasmic when unligated; translocates to nucleus upon ligand binding or in presence of RACK1. |
Background
The androgen receptor gene spans more than 90 kb and encodes a protein with three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The receptor acts as a steroid-hormone activated transcription factor. Upon ligand binding, it dissociates from accessory proteins, translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
This gene includes two polymorphic trinucleotide repeat segments encoding polyglutamine and polyglycine tracts. Expansion of the polyglutamine tract from normal 9–34 repeats to 38–62 repeats leads to spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encode distinct isoforms.
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