ELK Biotechnology AR (phospho Ser213) rabbit pAb

제품명

AR (phospho Ser213) rabbit pAb

제품 개요

이 항체는 인간 안드로겐 수용체(Androgen Receptor)의 Ser213 인산화 부위를 인식하도록 제작된 rabbit polyclonal antibody입니다. IHC, IF, ELISA 등 다양한 응용에 적합하며, 핵 및 세포질 내 단백질 위치 연구에 활용할 수 있습니다.

제품 정보

Background

The androgen receptor (AR) gene spans over 90 kb and encodes a protein with three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. AR acts as a steroid hormone-activated transcription factor. Upon ligand binding, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes. The gene contains polymorphic trinucleotide repeats encoding polyglutamine and polyglycine tracts; expansion of the polyglutamine tract (38–62 repeats) causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been identified.