ELK Biotechnology AR (phospho Ser213) rabbit pAb
인간, 쥐, 생쥐에서 인식되는 AR (phospho Ser213) rabbit polyclonal antibody. IHC, IF, ELISA에 적합하며, 핵 및 세포질 내 안드로겐 수용체 인산화 형태 검출에 활용. 합성 펩타이드 유래 면역원 사용, -20°C에서 1년 보관 가능.
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제품명
AR (phospho Ser213) rabbit pAb
제품 개요
이 항체는 인간 안드로겐 수용체(Androgen Receptor)의 Ser213 인산화 부위를 인식하도록 제작된 rabbit polyclonal antibody입니다. IHC, IF, ELISA 등 다양한 응용에 적합하며, 핵 및 세포질 내 단백질 위치 연구에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | AR (phospho Ser213) rabbit pAb |
| Alternative Names | AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Androgen Receptor around the phosphorylation site of Ser213 (AA range: 186–235) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 367 |
| Human Swiss-Prot No. | P10275 |
| Cellular Localization | Nucleus, Cytoplasm. Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. |
| Species Reactivity | Human; Rat; Mouse |
Background
The androgen receptor (AR) gene spans over 90 kb and encodes a protein with three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. AR acts as a steroid hormone-activated transcription factor. Upon ligand binding, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes. The gene contains polymorphic trinucleotide repeats encoding polyglutamine and polyglycine tracts; expansion of the polyglutamine tract (38–62 repeats) causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been identified.
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