원본
ELK Biotechnology Insulin R rabbit pAb
상품 한눈에 보기
인슐린 수용체(Insulin Receptor, INSR)에 특이적인 토끼 폴리클로날 항체로, IHC, IF, WB, ELISA 등 다양한 실험에 사용 가능. 인간, 쥐, 랫드, 돼지 시료에 반응하며, 세포막 및 리소좀 등에서 발현 단백질 검출에 적합. -20°C에서 1년 보관 가능.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다회원가입 없이 바로 구매하세요
가입하지 않아도 비회원가로 구매하실 수 있습니다.
카탈로그 번호 · 상품 설명출고판매가담기
ELK Biotechnology ES5912-100UL Insulin R rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES5912-50UL Insulin R rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Insulin R rabbit pAb
제품명
Insulin R rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | INSR; Insulin receptor; IR; CD antigen CD220 |
| Applications | IHC; IF; WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IR. AA range: 1326–1375 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 155 kD |
| Gene ID (Human) | 3643 |
| Human Swiss-Prot No | P06213 |
| Species Reactivity | Human; Rat; Mouse; Pig |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Late endosome; Lysosome. Binding of insulin to INSR induces internalization and lysosomal degradation of the receptor. In the presence of SORL1, internalized INSR molecules are redirected back to the cell surface, preventing lysosomal catabolism and strengthening insulin signal reception. |
| Background | This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome, and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. (RefSeq, Oct 2015) |
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.