ELK Biotechnology Insulin R (phospho Tyr1361) rabbit pAb
인슐린 수용체 인산화 부위(Tyr1361)를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 세포막 및 리소좀 위치 단백질 연구에 적합. -20°C에서 1년 보관.
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제품명
Insulin R (phospho Tyr1361) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | INSR; Insulin receptor; IR; CD antigen CD220 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human IR around the phosphorylation site of Tyr1361 (AA range: 1331–1380) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 95 kDa |
| Gene ID (Human) | 3643 |
| Human Swiss-Prot No | P06213 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Late endosome; Lysosome. Binding of insulin to INSR induces internalization and lysosomal degradation of the receptor, down-regulating this signaling pathway after stimulation. In the presence of SORL1, internalized INSR molecules are redirected back to the cell surface, preventing lysosomal catabolism and strengthening insulin signal reception. |
Background
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is processed to generate alpha and beta subunits forming a heterotetrameric receptor. Binding of insulin or other ligands activates the insulin signaling pathway, regulating glucose uptake and release, as well as carbohydrate, lipid, and protein metabolism. Mutations in this gene cause inherited severe insulin resistance syndromes including type A insulin resistance, Donohue syndrome, and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [RefSeq, Oct 2015]
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