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ELK Biotechnology Insulin R (phospho Tyr1355) rabbit pAb
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인슐린 수용체의 Tyr1355 인산화 부위를 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 쥐, 생쥐 시료에 반응하며 세포막 단백질 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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- pk
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ELK Biotechnology ES5908-100UL Insulin R (phospho Tyr1355) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES5908-50UL Insulin R (phospho Tyr1355) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Insulin R (phospho Tyr1355) rabbit pAb
제품명
Insulin R (phospho Tyr1355) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | INSR; Insulin receptor; IR; CD antigen CD220 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IR around the phosphorylation site of Tyr1355. AA range: 1326–1375 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 95 kD |
| Gene ID (Human) | 3643 |
| Human Swiss-Prot No. | P06213 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Late endosome; Lysosome. Binding of insulin to INSR induces internalization and lysosomal degradation of the receptor, a means for down-regulating this signaling pathway after stimulation. In the presence of SORL1, internalized INSR molecules are redirected back to the cell surface, thereby preventing their lysosomal catabolism and strengthening insulin signal reception. |
| Background | This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids, and protein. Mutations in this gene underlie inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome, and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. (RefSeq, Oct 2015) |
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