ELK Biotechnology Insulin R (phospho Thr1375) rabbit pAb

제품명

Insulin R (phospho Thr1375) rabbit pAb

기본 정보

세포 내 위치

Cell membrane; Single-pass type I membrane protein; Late endosome; Lysosome.
Binding of insulin to INSR induces internalization and lysosomal degradation of the receptor, a means for down-regulating this signaling pathway after stimulation.
In the presence of SORL1, internalized INSR molecules are redirected back to the cell surface, thereby preventing their lysosomal catabolism and strengthening insulin signal reception.

유전자 배경

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor.
Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids, and proteins.
Mutations in this gene underlie inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome, and Rabson-Mendenhall syndrome.
Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]