ELK Biotechnology SHIP-1 rabbit pAb
SHIP-1 rabbit pAb는 인간, 마우스, 랫트에 반응하는 다클론 항체로 WB, ELISA, IHC에 적합합니다. 세포막 및 세포질에 위치한 SHIP-1 단백질 검출에 사용되며, 면역세포 신호 조절 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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SHIP-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | INPP5D; SHIP; SHIP1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1 |
| Applications | WB, ELISA, IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SHIP1 (AA range: 987–1036) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 133 kDa |
| Gene ID (Human) | 3635 |
| Human Swiss-Prot No. | Q92835 |
| Species Reactivity | Human, Mouse, Rat |
| Cellular Localization | Cytoplasm, Cell membrane (Peripheral membrane protein), Membrane raft, Cytoskeleton. Translocates to the plasma membrane when activated, depending on cell type and stimulus. Colocalizes with FC-gamma-RIIB receptor (FCGR2B) or FCGR3/CD16 at membrane ruffles. Tyrosine phosphorylation may also contribute to membrane localization. |
Background
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells, where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5′ phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system.
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