ELK Biotechnology IL-12A rabbit pAb
IL-12A 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포 분비형 사이토카인 연구에 적합하며 IFN-γ 유도 및 Th1/Th2 분화 연구에 활용.
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제품명
IL-12A rabbit pAb
공급업체
ELK Biotechnology
제품 개요
IL-12A 단백질을 인식하는 토끼 유래 폴리클로날 항체로, 다양한 면역학적 분석에 사용됩니다. IL-12A는 T세포 및 NK세포에 작용하는 사이토카인으로, 면역 반응 조절에 중요한 역할을 합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | IL-12A rabbit pAb |
| Alternative Names | IL12A; NKSF1; Interleukin-12 subunit alpha; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; NK cell stimulatory factor chain 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1/50–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human IL-12A (AA range: 16–65) |
| Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kD |
| GeneID (Human) | 3592 |
| Human Swiss-Prot No | P29459 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
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